A REVIEW OF PALMITOYLETHANOLAMIDE

The reviewers will file critical information from included article content in the Microsoft Excel data extraction kind designed a priori. Two reviewers (AA and GP) will independently extract knowledge to reduce mistakes.1996). Oral PEA also reduced paw oedema induced by carrageenan, dextran and formalin, suggesting the compound right down‐modulat

2015). These scientific studies, taken jointly, suggest that, While a direct activation of GPR55 or PPAR‐α happens, PEA can generate its anti‐inflammatory motion in the gut also via indirect activation of CB1 and CB2 receptors, most likely on account of the power of this compound to potentiate the action of endocannabinoids at these receptors.